Inhibition of Tumor Metastasis: Functional Immune Modulation of the CUB Domain Containing Protein 1
نویسندگان
چکیده
منابع مشابه
Functional role of cell surface CUB domain-containing protein 1 in tumor cell dissemination.
The function of CUB domain-containing protein 1 (CDCP1), a recently described transmembrane protein expressed on the surface of hematopoietic stem cells and normal and malignant cells of different tissue origin, is not well defined. The contribution of CDCP1 to tumor metastasis was analyzed by using HeLa carcinoma cells overexpressing CDCP1 (HeLa-CDCP1) and a high-disseminating variant of prost...
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Tumor metastasis is a complex multistep process by which cells from the primary tumor invade tissues, move through the vasculature, settle at distant sites and eventually grow to form secondary tumors. Altered tyrosine phosphorylation signals in cancer cells contribute to a number of aberrant characteristics involved in tumor invasion and metastasis. CUB domain-containing protein 1 (CDCP1) is a...
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We report the application of quantitative mass spectrometry to identify plasma membrane proteins differentially expressed in melanoma cells with high vs. low metastatic abilities. Using stable isotope labeling with amino acids in culture (SILAC) coupled with nanospray tandem mass spectrometry, we identified CUB-domain-containing protein 1 (CDCP1) as one such differentially expressed transmembra...
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15 صفحه اولAtlas of Genetics and Cytogenetics in Oncology and Haematology CDCP 1 ( CUB domain containing protein 1 )
Review on CDCP1, with data on DNA/RNA, on the protein encoded and where the gene is implicated.
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ژورنال
عنوان ژورنال: Molecular Pharmaceutics
سال: 2009
ISSN: 1543-8384,1543-8392
DOI: 10.1021/mp900236t